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T1ρ imaging in premanifest Huntington disease reveals changes associated with disease progression.

Identifieur interne : 000051 ( Main/Exploration ); précédent : 000050; suivant : 000052

T1ρ imaging in premanifest Huntington disease reveals changes associated with disease progression.

Auteurs : Shafik N. Wassef [États-Unis] ; John Wemmie [États-Unis] ; Casey P. Johnson [États-Unis] ; Hans Johnson [États-Unis] ; Jane S. Paulsen [États-Unis] ; Jeffrey D. Long [États-Unis] ; Vincent A. Magnotta [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.

RBID : pubmed:25820773

Abstract

Imaging biomarkers sensitive to Huntington's disease (HD) during the premanifest phase preceding motor diagnosis may accelerate identification and evaluation of potential therapies. For this purpose, quantitative MRI sensitive to tissue microstructure and metabolism may hold great potential. We investigated the potential value of T1ρ relaxation to detect pathological changes in premanifest HD (preHD) relative to other quantitative relaxation parameters.

DOI: 10.1002/mds.26203
PubMed: 25820773

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Imaging biomarkers sensitive to Huntington's disease (HD) during the premanifest phase preceding motor diagnosis may accelerate identification and evaluation of potential therapies. For this purpose, quantitative MRI sensitive to tissue microstructure and metabolism may hold great potential. We investigated the potential value of T1ρ relaxation to detect pathological changes in premanifest HD (preHD) relative to other quantitative relaxation parameters.</div>
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Movement Disorders (revue)

T1ρ imaging in premanifest Huntington disease reveals changes associated with disease progression.

T1ρ imaging in premanifest Huntington disease reveals changes associated with disease progression.

Source :

Abstract

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	Movement Disorders (revue)
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